A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...

This toxin, called colibactin, is made by certain strains of E. coli and other microbes that naturally live in the human gut.

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...

To our immune system, a potentially lifesaving gene therapy can look a lot like a dangerous infection. That's because most ...